Article

Systematic Evaluation of High-Throughput PBK Modelling Strategies for the Prediction of Intravenous and Oral Pharmacokinetics in Humans

2024-03-25

Abstract excerpt

Physiologically based kinetic (PBK) modelling offers a mechanistic basis for predicting the pharmaco-/toxicokinetics of compounds and thereby provides critical information for integrating toxicity and exposure data to replace animal testing with in vitro or in silico methods. However, traditional PBK modelling depends on animal and human data, which limits its usefulness for Non-Animal Methods. To address this l...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5c6e6082-830b-5ed9-bd39-36561284ff46
DOI: 10.1101/2024.03.20.585001

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Systematic Evaluation of High-Throughput PBK Modelling Strategies for the Prediction of Intravenous and Oral Pharmacokinetics in HumansDOI 10.1101/2024.03.20.585001Read

High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokineticsSemantic proximity Read

High-throughput PBTK models for in vitro to in vivo extrapolationSemantic proximity Read

Computational Prediction of CNS Drug Exposure Based on a Novel In Vivo DatasetSemantic proximity Read

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAMs) in Pharmaceuticals and Environmental Chemical Risk AssessmentSemantic proximity Read

A machine learning approach to population pharmacokinetic modelling automationSemantic proximity Read

PD Union An Automated Pharmacodynamic Modeling Framework Based on a Unified Mechanistic Skeleton and Machine Learning AssistanceSemantic proximity Read

A Human Next Generation PBK Model for PFOASemantic proximity Read

Establishing a framework for human dose prediction in anti-tuberculosis drug developmentSemantic proximity Read

Advancements in Virtual Bioequivalence: Computational Methods and Regulatory Perspectives in the Pharmaceutical IndustrySemantic proximity Read

Clinical pharmacokinetic registration file for NDA and ANDA procedures.Semantic proximity Read

A Digital Twin of Glimepiride for Personalized and Stratified Diabetes TreatmentSemantic proximity Read

Predicting human pharmacokinetics from preclinical data: clearanceSemantic proximity Read