Article

The Role of “Physiologically Based Pharmacokinetic Model (PBPK)” New Approach Methodology (NAMs) in Pharmaceuticals and Environmental Chemical Risk Assessment

2022-12-30

Abstract excerpt

Physiologically Based Pharmacokinetic Models (PBPK) are mechanistical tools generally employed in the pharmaceutical industry and environmental health risk assessment. These models are recognised by regulatory authorities for predicting organ concentration-time profile, pharmacokinetic and daily intake dose of xenobiotics. Extension of PBPK models to capture sensitive populations like pediatric, geriatric, pregnan...

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Literature Corpus work: 5b8fffdb-3a63-5731-8e47-29108a5835d7
DOI: 10.20944/preprints202212.0564.v1

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