Article

Cosmetics Europe evaluation of 6 in silico skin penetration models

2021-07-09

Abstract excerpt

The ADME TF aims to develop in silico skin penetration models using in vitro human skin penetration data for 25 chemicals solubilized in wataer. Since there are widely differing opinions on different in silico models, we evaluated 3 open source (DermWin™, CDC and the University of Surrey models) and 3 commercial models (DSkin, SimCyp and TCAT). Simulation of cutaneous distribution used a finite dose exposure scena...

Identifiers and source

Literature Corpus work: 2627b4ef-8205-5b10-bdb6-b4c6145da34c
DOI: 10.1016/j.comtox.2021.100177

Open publication

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