Article
Atypical prion diseases in humans and animals.
Topics in current chemistry - 1 Jan 2011
Tranulis Michael A, Benestad Sylvie L, Baron Thierry, Kretzschmar Hans
Abstract excerpt
Although prion diseases, such as Creutzfeldt-Jakob disease (CJD) in humans and scrapie in sheep, have long been recognized, our understanding of their epidemiology and pathogenesis is still in its early stages. Progress is hampered by the lengthy incubation periods and the lack of effective ways of monitoring and characterizing these agents. Protease-resistant conformers of the prion protein (PrP), known as the...
Topics
- Alleles
- Animals
- Cattle
- Creutzfeldt-Jakob Syndrome
- Encephalopathy, Bovine Spongiform
- Genotype
- Humans
- Mice
- Mice, Transgenic
- Prion Diseases
- Risk
- Scrapie