Article
Effects of knockdown of autophagy pathway genes on <i>C. elegans</i> longevity are highly condition dependent
2025-07-31
Abstract excerpt
Autophagy is proposed to protect against aging by clearing damaged cellular constituents. In line with this several life-extending interventions in model organisms show some degree of autophagy dependence. In C. elegans , inhibiting autophagy can shorten, lengthen or have no effect on lifespan. Differences between published findings likely reflect variability in experimental conditions. Here we investigate the co...
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Identifiers and source
- Literature Corpus work
- db6e8c8e-325d-5b0f-9a23-a7569c5e5e90
- DOI
- 10.1101/2025.07.28.667102