Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

Abstract excerpt

Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila and is sufficient on its own to increase lifespan. We first established that the well-characterised lifespan extension associated with deletion of the insulin receptor substrate chico was...

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• Autophagy in Disease and Therapy
• Genetics, Aging, and Longevity in Model Organisms