Article

A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity

2022-02-15

Abstract excerpt

<title>Abstract</title> <p>Background Colorectal cancer (CRC) is one of the most common malignancies and the patient survival rate remains unacceptably low. The anti-programmed cell death-1 (PD-1)/programmed cell death ligand 1 (PD-L1) antibody-based immune checkpoint inhibitors have been added to CRC treatment regimens, however, only a fraction of patients benefits. As an important co-stimulatory molecule, 4-1B...

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Literature Corpus work: c5e8d724-9003-5226-b3a6-578958e8c654
DOI: 10.21203/rs.3.rs-1352893/v1

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