From Small Molecules to Degraders and AI: Contemporary Trends and Future Directions in Anticancer Drug Discovery

Abstract excerpt

Cancer remains one of the leading causes of death worldwide, demanding continuous innovation in therapeutic strategies. Traditional chemotherapeutic agents, though effective in certain contexts, are limited by systemic toxicity, drug resistance, and non-specific targeting. Over the past two decades, the landscape of anticancer drug discovery has undergone a paradigm shift with the emergence of molecularly targeted...

Topics

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• Antineoplastic Agents
• Computer Simulation
• Immunoconjugates
• Mutation
• Neoplasms
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

1e6949a0-aaae-533e-9d8d-970af055b150

DOI

10.20944/preprints202510.2242.v1