Article

Harnessing Transcriptomic Signals for Amyotrophic Lateral Sclerosis to Identify Novel Drugs and Enhance Risk Prediction

2023-01-18

Abstract excerpt

<h4>Introduction</h4> Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. This study integrates the latest ALS genome-wide association study (GWAS) summary statistics with functional genomic annotations with the aim of providing mechanistic insights into ALS risk loci, inferring drug repurposing opportunities, and enhancing prediction of ALS risk and clinical characteristics. <h4>Methods</h4>...

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Literature Corpus work: 9126f743-2161-5918-a70e-c1b2a7babf5e
DOI: 10.1101/2023.01.18.23284589

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