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Article

Discovery and Exploration of Lipid-Modifying Drug Targets for ALS by Mendelian Randomization.

Molecular neurobiology - 1 Sept 2024

Jiang Zheng, Gu Xiao-Jing, Su Wei-Ming, Duan Qing-Qing, Yin Kang-Fu, Ren Yan-Lin, Wang Yi, Cao Bei, Chen Yong-Ping

Abstract excerpt

Observational studies have faced challenges in identifying replicable causes for amyotrophic lateral sclerosis (ALS). To address this, we employed an unbiased and data-driven approach to discover and explore potential causal exposures using two-sample Mendelian randomization (MR) analyses. In the phenotype discovery stage, we assessed 3948 environmental exposures from the UK Biobank and utilized ALS summary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38324182
DOI: 10.1007/s12035-024-04007-9

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