Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis.

Oncogene - 29 Aug 2002

Berchem Guy, Glondu Murielle, Gleizes Michel, Brouillet Jean-Paul, Vignon Françoise, Garcia Marcel, Liaudet-Coopman Emmanuelle

Abstract excerpt

Cathepsin-D is an independent marker of poor prognosis in human breast cancer. We previously showed that human wild-type cathepsin-D, as well as its mutated form devoid of proteolytic activity stably transfected in 3Y1-Ad12 cancer cells, stimulated tumor growth. To investigate the mechanisms by which human cathepsin-D and its catalytically-inactive counterpart promoted tumor growth in vivo, we quantified the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cathepsin D

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Division

Share to Mice, Inbred BALB C

Share to Neovascularization, Pathologic

Share to Proliferating Cell Nuclear Antigen

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 12185597
DOI: 10.1038/sj.onc.1205745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis.PMID 12185597Read ↗

A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells.Semantic proximity Read ↗

Cysteine cathepsins: From diagnosis to targeted therapy of cancerSemantic proximity Read ↗

Complexity of cancer protease biology: Cathepsin K expression and function in cancer progressionSemantic proximity Read ↗

Dual contrasting roles of cysteine cathepsins in cancer progression: Apoptosis versus tumour invasionSemantic proximity Read ↗

Multiple Roles for Cysteine Cathepsins in CancerSemantic proximity Read ↗

Cathepsin B as a cancer targetSemantic proximity Read ↗

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.Semantic proximity Read ↗

Overexpression of transfected cathepsin D in transformed cells increases their malignant phenotype and metastatic potency.Semantic proximity Read ↗

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expressionSemantic proximity Read ↗

Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowthSemantic proximity Read ↗

Hypercholesterolemia Induces Angiogenesis and Accelerates Growth of Breast Tumors in VivoSemantic proximity Read ↗

B Cells Promote Tumor Progression via STAT3 Regulated-AngiogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.