Article

Amyloid forming human lysozyme intermediates are stabilised by non-native amide-π interactions

2024-12-20

Abstract excerpt

Mutational variants of human lysozyme cause a rare but fatal hereditary form of systemic amyloidosis by populating an intermediate state that self-assembles into amyloid fibrils. Despite its significance in lysozyme amyloidosis, the intermediate state has been recalcitrant to detailed structural investigation as it is only transiently and sparsely populated. Here, we investigated the intermediate state of a mutati...

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Literature Corpus work: db2f31fb-38b0-5a2d-853f-d0fe75cab84e
DOI: 10.1101/2024.12.20.629167

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Amyloid forming human lysozyme intermediates are stabilised by non-native amide-π interactionsDOI 10.1101/2024.12.20.629167Read

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