Article
The Significance of the Location of Mutations for the Native-State Dynamics of Human Lysozyme.
Biophysical journal - 6 Dec 2016
Ahn Minkoo, Hagan Christine L, Bernardo-Gancedo Ana, De Genst Erwin, Newby Francisco N, Christodoulou John, Dhulesia Anne, Dumoulin Mireille, Robinson Carol V, Dobson Christopher M, Kumita Janet R
Abstract excerpt
The conversion of human lysozyme into amyloid fibrils is associated with a rare but fatal hereditary form of nonneuropathic systemic amyloidosis. The accumulation of large amounts of aggregated protein is thought to be initiated by the formation of transient intermediate species of disease-related lysozyme variants, essentially due to the loss of global cooperativity under physiologically relevant conditions....
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