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Article

Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme.

Nature structural biology - 1 Apr 2002

Canet Denis, Last Alexander M, Tito Paula, Sunde Margaret, Spencer Andrew, Archer David B, Redfield Christina, Robinson Carol V, Dobson Christopher M

Abstract excerpt

Hydrogen exchange experiments monitored by NMR and mass spectrometry reveal that the amyloidogenic D67H mutation in human lysozyme significantly reduces the stability of the beta-domain and the adjacent C-helix in the native structure. In addition, mass spectrometric data reveal that transient unfolding of these regions occurs with a high degree of cooperativity. This behavior results in the occasional population...

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Identifiers

PMID: 11887182
DOI: 10.1038/nsb768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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