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Article

Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.

Journal of molecular biology - 25 Feb 2005

Dumoulin Mireille, Canet Denis, Last Alexander M, Pardon Els, Archer David B, Muyldermans Serge, Wyns Lode, Matagne Andre, Robinson Carol V, Redfield Christina, Dobson Christopher M

Abstract excerpt

One of the 20 or so human amyloid diseases is associated with the deposition in vital organs of full-length mutational variants of the antibacterial protein lysozyme. Here, we report experimental data that permit a detailed comparison to be made of the behaviour of two of these amyloidogenic variants, I56T and D67H, under identical conditions. Hydrogen/deuterium exchange experiments monitored by NMR and mass...

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Share to Amyloidosis, Familial
Share to Antibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enzyme Stability

Share to Muramidase

Share to Nuclear Magnetic Resonance, Biomolecular

Share to Protein Denaturation

Share to Spectrometry, Mass, Electrospray Ionization

Source

Identifiers

PMID: 15713462
DOI: 10.1016/j.jmb.2004.11.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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