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Article

Characterization of the structure and dynamics of amyloidogenic variants of human lysozyme by NMR spectroscopy.

Protein science : a publication of the Protein Society - 1 Dec 2001

Chamberlain A K, Receveur V, Spencer A, Redfield C, Dobson C M

Abstract excerpt

The structures and dynamics of the native states of two mutational variants of human lysozyme, I56T and D67H, both associated with non-neuropathic systemic amyloidosis, have been investigated by NMR spectroscopy. The (1)H and (15)N main-chain amide chemical shifts of the I56T variant are very similar to those of the wild-type protein, but those of the D67H variant are greatly altered for 28 residues in the...

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Identifiers

PMID: 11714920
DOI: 10.1110/ps.28101
PMCID: PMC2374041

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Source receipt: pubmed, retrieved 7 Sept 2026.

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