Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection.

BioMed research international - 1 Jan 2021

Saih Asmae, Baba Hana, Bouqdayr Meryem, Ghazal Hassan, Hamdi Salsabil, Kettani Anass, Wakrim Lahcen

Abstract excerpt

SARS-CoV-2 coronavirus uses for entry to human host cells a SARS-CoV receptor of the angiotensin-converting enzyme (ACE2) that catalyzes the conversion of angiotensin II into angiotensin (1-7). To understand the effect of ACE2 missense variants on protein structure, stability, and function, various bioinformatics tools were used including SIFT, PANTHER, PROVEAN, PolyPhen2.0, I. Mutant Suite, MUpro, SWISS-MODEL,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Angiotensin-Converting Enzyme 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Computational Biology

Share to Computer Simulation

Share to COVID-19

Share to Mutation, Missense

Share to Polymorphism, Single Nucleotide

Share to SARS-CoV-2

Source

Open in PubMed Open full text

Identifiers

PMID: 33884270
DOI: 10.1155/2021/6685840
PMCID: PMC8040925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection.PMID 33884270Read ↗

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)Semantic proximity Read ↗

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).Semantic proximity Read ↗

Genetic Variations in the Human Angiotensin-ConvertingEnzyme 2 and Susceptibility to Coronavirus Disease-19.Semantic proximity Read ↗

Investigating the ACE2 polymorphisms in COVID-19 susceptibility: An in silico analysis.Semantic proximity Read ↗

COVID-19 genomic susceptibility: Definition of <i>ACE2</i> variants relevant to human infection with SARS-CoV-2 in the context of ACMG/AMP GuidanceSemantic proximity Read ↗

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibilitySemantic proximity Read ↗

Genetic variations in the human severe acute respiratory syndrome coronavirus receptor ACE2 and serine protease TMPRSS2.Semantic proximity Read ↗

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.Semantic proximity Read ↗

SARS-CoV-2 infection susceptibility influenced by ACE2 genetic polymorphisms: insights from Tehran Cardio-Metabolic Genetic Study.Semantic proximity Read ↗

Computational Analysis of Missense Variants in the Human Transmembrane Protease Serine 2 (TMPRSS2) and SARS-CoV-2.Semantic proximity Read ↗

Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and traffickingSemantic proximity Read ↗

Susceptibilities of human ACE2 genetic variants in coronavirus infectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.