Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).

Journal of translational medicine - 24 Aug 2020

Guo Xingyi, Chen Zhishan, Xia Yumin, Lin Weiqiang, Li Hongzhi

Abstract excerpt

BACKGROUND: The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiotensin-converting enzyme 2 (ACE2) in humans. However, it remains unclear how genetic variations in ACE2 may affect its function and structure, and consequently alter the recognition by SARS-CoV-2....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme 2
Share to Betacoronavirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coronavirus Infections

Share to Molecular Docking Simulation

Share to Pandemics

Share to Pneumonia, Viral

Share to Spike Glycoprotein, Coronavirus

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 32831104
DOI: 10.1186/s12967-020-02486-7
PMCID: PMC7443814

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).PMID 32831104Read ↗

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)Semantic proximity Read ↗

In Silico Analysis of High-Risk Missense Variants in Human ACE2 Gene and Susceptibility to SARS-CoV-2 Infection.Semantic proximity Read ↗

Molecular docking simulation reveals ACE2 polymorphisms that may increase the affinity of ACE2 with the SARS-CoV-2 Spike protein.Semantic proximity Read ↗

Human ACE2 receptor polymorphisms predict SARS-CoV-2 susceptibilitySemantic proximity Read ↗

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein.Semantic proximity Read ↗

Genetic variations in the human severe acute respiratory syndrome coronavirus receptor ACE2 and serine protease TMPRSS2.Semantic proximity Read ↗

Missense variants in ACE2 are predicted to encourage and inhibit interaction with SARS-CoV-2 Spike and contribute to genetic risk in COVID-19Semantic proximity Read ↗

Investigating the ACE2 polymorphisms in COVID-19 susceptibility: An in silico analysis.Semantic proximity Read ↗

SARS-CoV-2 infection susceptibility influenced by ACE2 genetic polymorphisms: insights from Tehran Cardio-Metabolic Genetic Study.Semantic proximity Read ↗

Genetic Variations in the Human Angiotensin-ConvertingEnzyme 2 and Susceptibility to Coronavirus Disease-19.Semantic proximity Read ↗

Susceptibilities of human ACE2 genetic variants in coronavirus infectionSemantic proximity Read ↗

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.