Article

Death-seq identifies regulators of cell death and senolytic therapies

2022-04-03

Abstract excerpt

<h4>SUMMARY</h4> Selectively ablating senescent cells (“senolysis”) is an evolving therapeutic approach for age-related diseases. Current senolytics are limited to local administration by potency and side effects. While genetic screens could identify senolytics, current screens are underpowered for identifying genes that regulate cell death due to limitations in screen methodology. Here, we establish Death-seq, a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db0b25c5-fa04-56f4-b7ff-77bc709f9cb2
DOI: 10.1101/2022.04.01.486768

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Death-seq identifies regulators of cell death and senolytic therapiesDOI 10.1101/2022.04.01.486768Read

Death-seq identifies regulators of cell death and senolytic therapiesSemantic proximity Read

From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugsSemantic proximity Read

Senolytics: Targeting Senescent Cells for Age-Associated DiseasesSemantic proximity Read

Discovery, development, and future application of senolytics: theories and predictions.Semantic proximity Read

A second generation of senotherapies: the development of targeted senolytics, senoblockers and senoreversers for healthy ageingSemantic proximity Read

Recent Advances in Senolysis for Age-Related DiseasesSemantic proximity Read

Development of novel flavonoid senolytics through phenotypic drug screening and drug designSemantic proximity Read

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.Semantic proximity Read

Current senolytics: Mode of action, efficacy and limitations, and their future.Semantic proximity Read

Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell typesSemantic proximity Read

Single-cell-based evidence for GLS1 inhibitor as a bona fide senolytic agent in vivoSemantic proximity Read

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stressSemantic proximity Read