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Development of novel flavonoid senolytics through phenotypic drug screening and drug design

2024-10-27

Abstract excerpt

Accumulation of senescent cells drives aging and age-related diseases. Senolytics, which selectively kill senescent cells, offer a promising approach for treating many age-related diseases. Using a senescent cell-based phenotypic drug discovery approach that combines drug screening and drug design, we developed two novel flavonoid senolytics, SR29384 and SR31133, derived from the senolytic fisetin. These compounds...

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Identifiers and source

Literature Corpus work
59009d90-623f-50f4-affb-24abdf7a7666
DOI
10.1101/2024.10.27.620529
Open publication

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Development of novel flavonoid senolytics through phenotypic drug screening and drug designDOI 10.1101/2024.10.27.620529
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