Discovery, development, and future application of senolytics: theories and predictions.

Abstract excerpt

Senescent cells accumulate with aging and at etiological sites of multiple diseases, including those accounting for most morbidity, mortality, and health costs. Senescent cells do not replicate, can release factors that cause tissue dysfunction, and yet remain viable. The discovery of senolytic drugs, agents that selectively eliminate senescent cells, created a new route for alleviating age-related dysfunction...

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• Cellular Senescence
• Clinical Trials as Topic
• Computational Biology
• Drug Development
• Genetics, Aging, and Longevity in Model Organisms