Back to search

Article

Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules <i>beat-Ia/CADM2</i>

2024-09-26

Abstract excerpt

Idiopathic hypersomnia (IH) is a poorly-understood sleep disorder characterized by excessive daytime sleepiness despite normal nighttime sleep. Combining human genomics with behavioral and mechanistic studies in fish and flies, we uncover a role for beat-Ia/CADM2 , synaptic adhesion molecules of the immunoglobulin superfamily, in excessive sleepiness. Neuronal knockdown of Drosophila beat-Ia results in sleepy fl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
db040c4f-ced0-5eb5-bc36-0e45d2df5429
DOI
10.1101/2024.09.25.615048
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules <i>beat-Ia/CADM2</i>DOI 10.1101/2024.09.25.615048
The atypical cadherin flamingo regulates synaptogenesis and helps prevent axonal and synaptic degeneration in Drosophila.Semantic proximity
Functions of synapse adhesion molecules neurexin/neuroligins and neurodevelopmental disorders.Semantic proximity
Combining Human Epigenetics and Sleep Studies in Caenorhabditis elegans: A Cross-Species Approach for Finding Conserved Genes Regulating SleepSemantic proximity
The chromatin remodeler ISWI acts during <i>Drosophila</i> development to regulate adult sleepSemantic proximity
Neurexin regulates nighttime sleep by modulating synaptic transmission.Semantic proximity
Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleepSemantic proximity
Loss of zebrafish <i>ctnnd2b</i> results in disorganised forebrain neuron clustersSemantic proximity
Neurexins.Semantic proximity
CTNND2 regulation by the SRGAP2 protein family links human evolution to synaptic neotenySemantic proximity
Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex.Semantic proximity
Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development.Semantic proximity
Cross-species variant-to-function analyses implicate <i>MEIS1</i> in conferring sleep abnormalities and impaired cerebellar developmentSemantic proximity
Select a neighboring publication to make it the new centre.