Article
Caenorhabditis elegans flamingo cadherin fmi-1 regulates GABAergic neuronal development.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Mar 2012
Najarro Elvis Huarcaya, Wong Lianna, Zhen Mei, Carpio Edgar Pinedo, Goncharov Alexandr, Garriga Gian, Lundquist Erik A, Jin Yishi, Ackley Brian D
Abstract excerpt
In a genetic screen for regulators of synaptic morphology, we identified the single Caenorhabditis elegans flamingo-like cadherin fmi-1. The fmi-1 mutants exhibit defective axon pathfinding, reduced synapse number, aberrant synapse size and morphology, as well as an abnormal accumulation of synaptic vesicles at nonsynaptic regions. Although FMI-1 is primarily expressed in the nervous system, it is not expressed...
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