Article
Neurexin regulates nighttime sleep by modulating synaptic transmission.
Scientific reports - 1 Dec 2016
Tong Huawei, Li Qian, Zhang Zi Chao, Li Yi, Han Junhai
Abstract excerpt
Neurexins are cell adhesion molecules involved in synaptic formation and synaptic transmission. Mutations in neurexin genes are linked to autism spectrum disorders (ASDs), which are frequently associated with sleep problems. However, the role of neurexin-mediated synaptic transmission in sleep regulation is unclear. Here, we show that lack of the Drosophila α-neurexin homolog significantly reduces the quantity...
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