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Distinct Synaptic Mechanisms Drive <i>NRXN1</i> Variant-Mediated Pathogenesis in iPSC-Derived Neuronal Models of Autism and Schizophrenia

2025-07-19

Abstract excerpt

Copy number deletions in the 2p16.3/ NRXN1 locus confer genome wide risk for autism spectrum disorder (ASD) and schizophrenia (SCZ). Prior work demonstrated that heterozygous NRXN1 deletions decreases synaptic strength and neurotransmitter release probability in human-iPSC derived cortical glutamatergic induced neurons and this synaptic phenotype is replicated in SCZ patient iPSCs with varying NRXN1 genomic del...

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Literature Corpus work
e493459a-87b1-536d-8801-093fc8f660ce
DOI
10.1101/2025.07.18.664735
Open publication

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