Article

Inhibition of sensory neuron driven acute, inflammatory, and neuropathic pain using a humanised chemogenetic system

2023-03-21

Abstract excerpt

Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means to suppress such excitability, yet chemogenetic approaches suitable for human applications are needed. PSAM 4 -GlyR is a modular system based on the human α7 nicotinic acetylcholine and glycine receptors, which responds to inert chemical ligands and...

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Literature Corpus work: daf7c150-91f3-55c7-8bec-97318dedf7dd
DOI: 10.1101/2023.03.21.533690

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