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Article

A humanized chemogenetic system inhibits murine pain-related behavior and hyperactivity in human sensory neurons.

Science translational medicine - 4 Oct 2023

Perez-Sanchez Jimena, Middleton Steven J, Pattison Luke A, Hilton Helen, Ali Awadelkareem Mosab, Zuberi Sana R, Renke Maria B, Hu Huimin, Yang Xun, Clark Alex J, St John Smith Ewan, Bennett David L

Abstract excerpt

Hyperexcitability in sensory neurons is known to underlie many of the maladaptive changes associated with persistent pain. Chemogenetics has shown promise as a means to suppress such excitability, yet chemogenetic approaches suitable for human applications are needed. PSAM4-GlyR is a modular system based on the human α7 nicotinic acetylcholine and glycine receptors, which responds to inert chemical ligands and...

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PMID: 37792955
DOI: 10.1126/scitranslmed.adh3839
PMCID: PMC7615191

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