Article
Proteins that bind A-type lamins: integrating isolated clues.
Journal of cell science - 1 Mar 2004
Zastrow Michael S, Vlcek Sylvia, Wilson Katherine L
Abstract excerpt
What do such diverse molecules as DNA, actin, retinoblastoma protein and protein kinase Calpha all have in common? They and additional partners bind 'A-type' lamins, which form stable filaments in animal cell nuclei. Mutations in A-type lamins cause a bewildering range of tissue-specific diseases, termed 'laminopathies', including Emery-Dreifuss muscular dystrophy and the devastating Hutchinson-Gilford progeria...
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