Article

Scleroderma-specific autoantibodies embedded in immune complexes mediate endothelial damage: an early event in the pathogenesis of systemic sclerosis

2020-10-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Consistently with their diagnostic and prognostic value, autoantibodies specific for systemic sclerosis (SSc) embedded in immune complexes (ICs) elicited a pro-inflammatory and pro-fibrotic cascade in healthy skin fibroblasts, engaging Toll-like Receptors (TLRs) via their nucleic acid components. The objective of this study was to investigate the pathogenicity o...

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Literature Corpus work: a59a7e68-a3fd-5956-ab88-5b85a4ce1ca2
DOI: 10.21203/rs.3.rs-18870/v2

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