Article

Isoform switching as a key mechanism in chemotherapy resistance in triple-negative breast cancer

2025-07-23

Abstract excerpt

<title>Abstract</title> <p>Background Triple-negative breast cancer (TNBC) is characterized by limited treatment options and high variability in response to neoadjuvant chemotherapy (NAC). While DNA-level alterations have been widely studied, post-transcriptional regulation through alternative splicing remains unexplored in this context. Methods We performed a transcriptome -wide analysis of differential isoform...

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Literature Corpus work: dacb2e5d-6147-585c-bd89-65f4100f9201
DOI: 10.21203/rs.3.rs-7041176/v1

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