Article

Landscape of reversion alterations in homologous recombination genes reveals evolutionary constraints

2026-05-21

Abstract excerpt

<h4>ABSTRACT</h4> Reversion mutations (REVs) restore homologous recombination repair (HRR) and confer resistance to PARP inhibitors (PARPi) in HR-deficient cancers. Yet, their prevalence, mechanisms, and biological constraints remain undefined. We analyzed genomic profiling of 609,464 tissue and liquid biopsy samples across multiple cancer types to delineate the pan-cancer landscape of REVs. REVs were identified...

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Literature Corpus work: 0653080a-033a-551f-860c-74d64f395f58
DOI: 10.64898/2026.05.19.726319

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