Article

Immune-evasion of <i>KRAS</i> -mutant lung adenocarcinoma mediated by cAMP response element-binding protein

2021-06-19

Abstract excerpt

cAMP response element-binding protein (CREB) mediates proliferative and inflammatory gene transcription in neurodegeneration and cancer, but its role in malignant immune-evasion of lung adenocarcinoma (LUAD) is unknown. We show that human LUAD of smokers are frequently altered along the CREB pathway and we employ mouse models to discover that KRAS -mutant LUAD co- opt CREB to evade immune rejection by tumoricidal...

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Literature Corpus work: dac83059-e63c-5ff5-a19e-083f74cdf2ab
DOI: 10.1101/2021.06.19.449094

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