Article

RNA regulates repeat-associated non-AUG (RAN) translation initiation in <i>C9orf72</i> FTD/ALS

2025-10-09

Abstract excerpt

Repeat-associated non-AUG (RAN) translation synthesizes protein in the absence of a cognate AUG start codon 1,2 In frontotemporal dementia and amyotrophic lateral sclerosis, a GGGGCC (G 4 C 2 ) repeat expansion in an intron of C9orf72 leads to synthesis of neurotoxic dipeptide-repeat proteins, underscoring the need to understand the mechanism of C9orf72 RAN translation 1-5 . RNA sequence and structure have b...

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Literature Corpus work: daa9d7ed-51fe-56b7-9d0a-3bd3dc6ce656
DOI: 10.1101/2025.10.09.681477

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