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Article

Ribosome profiling reveals novel regulation of C9ORF72 GGGGCC repeat-containing RNA translation

30 Nov 2021

Abstract excerpt

GGGGCC (G 4 C 2 ) repeat expansion in the first intron of C9ORF72 causes amyotrophic lateral sclerosis and frontotemporal dementia. Repeat-containing RNA is translated into dipeptide repeat (DPR) proteins, some of which are neurotoxic. Using dynamic ribosome profiling, we identified three translation initiation sites in the intron upstream of ( G 4 C 2 ) repeats; these sites are detected irrespective of the...

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PMID: 34848561
DOI: 10.1261/rna.078963.121

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