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Article

Tau proteins harboring neurodegeneration-linked mutations impair kinesin translocation in vitro.

Journal of Alzheimer's disease : JAD - 1 Jan 2014

Yu Dezhi, LaPointe Nichole E, Guzman Elmer, Pessino Veronica, Wilson Leslie, Feinstein Stuart C, Valentine Megan T

Abstract excerpt

We tested the hypothesis that mutant tau proteins that cause neurodegeneration and dementia differentially alter kinesin translocation along microtubules (MTs) relative to normal tau in vitro. We employed complementary in vitro motility assays using purified recombinant kinesin, purified recombinant tau, and purified bovine brain α:β tubulin to isolate interactions among these components without any contribution...

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PMID: 24150109
DOI: 10.3233/JAD-131274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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