The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches.

doi:10.1016/j.jbc.2022.102526

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Article

The N-terminal disease-associated R5L Tau mutation increases microtubule shrinkage rate due to disruption of microtubule-bound Tau patches.

The Journal of biological chemistry - 1 Nov 2022

Cario Alisa, Wickramasinghe Sanjula P, Rhoades Elizabeth, Berger Christopher L

Abstract excerpt

Regulation of the neuronal microtubule cytoskeleton is achieved through the coordination of microtubule-associated proteins (MAPs). MAP-Tau, the most abundant MAP in the axon, functions to modulate motor motility, participate in signaling cascades, as well as directly mediate microtubule dynamics. Tau misregulation is associated with a class of neurodegenerative diseases, known as tauopathies, including...

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PMID: 36162501
DOI: 10.1016/j.jbc.2022.102526
PMCID: PMC9589210

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