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Article

Domains of tau protein, differential phosphorylation, and dynamic instability of microtubules.

Molecular biology of the cell - 1 Dec 1995

Trinczek B, Biernat J, Baumann K, Mandelkow E M, Mandelkow E

Abstract excerpt

The dynamic instability of microtubules is thought to be regulated by MAPs and phosphorylation. Here we describe the effect of the neuronal microtubule-associated protein tau by observing the dynamics of single microtubules by video microscopy. We used recombinant tau isoforms and tau mutants, and we phosphorylated tau by the neuronal kinases MARK (affecting the KXGS motifs within tau's repeat domain) and cdk5...

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Identifiers

PMID: 8590813
DOI: 10.1091/mbc.6.12.1887
PMCID: PMC366657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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