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Article

Primary cilia mediate skeletogenic BMP and Hedgehog signaling in heterotopic ossification

24 Jul 2024

Abstract excerpt

Heterotopic ossification (HO), defined as the formation of extraskeletal bone in muscle and soft tissues, is a diverse pathological process caused by either genetic mutations or inciting trauma. Fibrodysplasia ossificans progressiva (FOP) is a genetic form of HO caused by mutations in the bone morphogenetic protein (BMP) type I receptor gene activin A receptor type 1 ( ACVR1 ). These mutations make ACVR1...

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PMID: 39047114
DOI: 10.1126/scitranslmed.abn3486

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