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Overactive bone morphogenetic protein signaling in heterotopic ossification and Duchenne muscular dystrophy

3 Jul 2012

Abstract excerpt

Bone morphogenetic proteins (BMPs) are important extracellular cytokines that play critical roles in embryogenesis and tissue homeostasis. BMPs signal via transmembrane type I and type II serine/threonine kinase receptors and intracellular Smad effector proteins. BMP signaling is precisely regulated and perturbation of BMP signaling is connected to multiple diseases, including musculoskeletal diseases. In this...

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PMID: 22752156
DOI: 10.1007/s00018-012-1054-x

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