Article

HIV-1 accessory protein Vpr possesses a cryptic p300-dependent transcription-promoting activity that is blocked by histone deacetylases in CD4 <sup>+</sup> T cells

2025-03-27

Abstract excerpt

Antiretroviral therapy (ART) has dramatically improved the clinical prognosis for people with HIV and prevents HIV transmission. However, ART does not cure HIV infection because of a persistent, latent reservoir in long-lived cells such as central memory CD4 + T (T CM ) cells. Eliminating or preventing reservoir formation will require a better understanding of HIV-1 latency establishment. We and others have rece...

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Literature Corpus work: daa32d10-7626-57c2-869c-8c02920cc493
DOI: 10.1101/2025.03.27.645672

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