Article

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrest

2023-05-23

Abstract excerpt

<h4>ABSTRACT</h4> Lentiviral accessory genes enhance replication through diverse mechanisms. HIV-1 accessory protein Vpr modulates the host DNA damage response (DDR) at multiple steps through DNA damage, cell cycle arrest, the degradation of host proteins, and both the activation and repression of DDR signaling. Vpr also alters host and viral transcription; however, the connection between Vpr-mediated DDR modulat...

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Literature Corpus work: b97b1e76-79b3-5a84-9cde-172cf12fde82
DOI: 10.1101/2023.05.23.541990

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