Article

Sex-specific hormone-sensitive regulatory architecture in adolescence as a scaffold for depression vulnerability

2026-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Adolescence is a critical developmental period during which sex differences in depression risk emerge, yet the underlying molecular mechanisms remain unclear. Here, we integrated longitudinal transcriptomic, epigenomic, and gene regulatory network analyses to characterize sex-specific regulatory dynamics of the brain across adolescence under normative conditions and elucidate how baseline molecu...

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Literature Corpus work: 7ba17432-02c0-59f5-93bf-b45d57c8af34
DOI: 10.64898/2026.05.06.723349

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