Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex Significantly Impacts the Function of Major Depression-Linked Variants In Vivo.

Biological psychiatry - 15 Sept 2023

Mulvey Bernard, Selmanovic Din, Dougherty Joseph D

Abstract excerpt

BACKGROUND: Genome-wide association studies have discovered blocks of common variants-likely transcriptional-regulatory-associated with major depressive disorder (MDD), though the functional subset and their biological impacts remain unknown. Likewise, why depression occurs in females more frequently than males is unclear. We therefore tested the hypothesis that risk-associated functional variants interact with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Depression
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 36803612
DOI: 10.1016/j.biopsych.2023.02.009
PMCID: PMC10425576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex Significantly Impacts the Function of Major Depression-Linked Variants In Vivo.PMID 36803612Read ↗

Sex significantly impacts the function of major depression-linked variants <i>in vivo</i>Semantic proximity Read ↗

Transcriptional-regulatory convergence across functional MDD risk variants identified by massively parallel reporter assays.Semantic proximity Read ↗

Transcriptional-Regulatory Convergence Across Functional MDD Risk Variants Identified by Massively Parallel Reporter AssaysSemantic proximity Read ↗

Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitrySemantic proximity Read ↗

Differential hippocampal gene expression and pathway analysis in an etiology-based mouse model of major depressive disorder.Semantic proximity Read ↗

Sex-specific hormone-sensitive regulatory architecture in adolescence as a scaffold for depression vulnerabilitySemantic proximity Read ↗

Molecular analyses of circadian gene variants reveal sex-dependent links between depression and clocks.Semantic proximity Read ↗

Transcriptional dissection of symptomatic profiles across the brain of men and women with depressionSemantic proximity Read ↗

Twin Study of Early-Onset Major Depression Finds DNA Methylation Enrichment for Neurodevelopmental GenesSemantic proximity Read ↗

Differential and spatial expression meta-analysis of genes identified in genome-wide association studies of depression.Semantic proximity Read ↗

Linking GWAS risk genes to transcriptional features of major depressive disorder via in vivo Perturb-seq.Semantic proximity Read ↗

Sex Differences in the Epigenome: A Cause or Consequence of Sexual Differentiation of the Brain?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.