Article

Pan-Specific and Partially Selective Dye-Labeled Peptidic Inhibitors of the Polycomb Paralog Proteins

2019-07-15

Abstract excerpt

Epigenetic regulation of gene expression is in part controlled by post-translational modifications on histone proteins. Histone methylation is a key epigenetic mark that controls gene transcription and repression. There are five human polycomb paralog proteins (Cbx2/4/6/7/8) which use their chromodomains to recognize trimethylated lysine 27 on Histone 3 (H3K27me3). Recognition of the methyllysine side chain is ach...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: da944752-a875-5f75-ae77-d518c6ac677c
DOI: 10.26434/chemrxiv.8866295.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pan-Specific and Partially Selective Dye-Labeled Peptidic Inhibitors of the Polycomb Paralog ProteinsDOI 10.26434/chemrxiv.8866295.v1Read

Polycomb Paralog Chromodomain Inhibitors Active Against Both CBX6 and CBX8Semantic proximity Read

REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATORSemantic proximity Read

A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulationSemantic proximity Read

A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine DifferentiationSemantic proximity Read

Targeting the “Undruggable”: Small-Molecule Inhibitors of Proliferating Cell Nuclear Antigen (PCNA) in the Spotlight in Cancer TherapySemantic proximity Read

Polycomb repressive complex 2 structure with inhibitor reveals a mechanism of activation and drug resistance.Semantic proximity Read

Structure of the PRC2 complex and application to drug discovery.Semantic proximity Read

PIC recruitment by synthetic reader-actuators to polycomb-silenced genes blocks triple-negative breast cancer invasionSemantic proximity Read

Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genomeSemantic proximity Read

Tailoring Peptidomimetics for Targeting Protein–Protein InteractionsSemantic proximity Read

Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.Semantic proximity Read

A computational design strategy for discovering the protein targets of histone lysine methyltransferasesSemantic proximity Read