Targeting the “Undruggable”: Small-Molecule Inhibitors of Proliferating Cell Nuclear Antigen (PCNA) in the Spotlight in Cancer Therapy

Abstract excerpt

PCNA plays multiple roles in cancer development, including cell proliferation regulation, DNA repair, replication, and serving as a widely used biomarker and therapeutic target. Despite its significant role in oncology, PCNA has historically been considered “undruggable” due to the absence of known endogenous small molecule modulators and identifiable ligand binding sites. Unlike other protein–protein interfaces,...

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