Article

REPROGRAMMING CBX8-PRC1 FUNCTION WITH A POSITIVE ALLOSTERIC MODULATOR

2021-02-23

Abstract excerpt

<h4> ABSTRACT </h4> Canonical targeting of Polycomb Repressive Complex 1 (PRC1) to repress developmental genes is mediated by cell type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7 and 8). Based on their central role in silencing and their misregulation associated with human disease including cancer, CBX proteins are attractive targets for small molecule chemical probe development. Here, we have...

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Literature Corpus work: 1408b782-c05a-5518-a1d0-aa049433b832
DOI: 10.1101/2021.02.23.432388

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