Article
A gain-of-function p53 mutant synergizes with oncogenic NRAS to promote acute myeloid leukemia in mice.
The Journal of clinical investigation - 15 Dec 2023
Rajagopalan Adhithi, Feng Yubin, Gayatri Meher B, Ranheim Erik A, Klungness Taylor, Matson Daniel R, Lee Moon Hee, Jung Mabel Minji, Zhou Yun, Gao Xin, Nadiminti Kalyan Vg, Yang David T, Tran Vu L, Padron Eric, Miyamoto Shigeki, Bresnick Emery H, Zhang Jing
Abstract excerpt
We previously demonstrated that a subset of acute myeloid leukemia (AML) patients with concurrent RAS pathway and TP53 mutations have an extremely poor prognosis and that most of these TP53 mutations are missense mutations. Here, we report that, in contrast to the mixed AML and T cell malignancy that developed in NrasG12D/+ p53-/- (NP-/-) mice, NrasG12D/+ p53R172H/+ (NPmut) mice rapidly developed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.