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Article

Activating STING1-dependent immune signaling in TP53 mutant and wild-type acute myeloid leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2022

Kogan Aksinija A, Topper Michael J, Dellomo Anna J, Stojanovic Lora, McLaughlin Lena J, Creed T Michael, Eberly Christian L, Kingsbury Tami J, Baer Maria R, Kessler Michael D, Baylin Stephen B, Rassool Feyruz V

Abstract excerpt

DNA methyltransferase inhibitors (DNMTis) reexpress hypermethylated genes in cancers and leukemias and also activate endogenous retroviruses (ERVs), leading to interferon (IFN) signaling, in a process known as viral mimicry. In the present study we show that in the subset of acute myeloid leukemias (AMLs) with mutations in TP53, associated with poor prognosis, DNMTis, important drugs for treatment of AML, enable...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 35759659
DOI: 10.1073/pnas.2123227119
PMCID: PMC9271208

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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