Article

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

2022-12-23

Abstract excerpt

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising therapeutic target for personalized medicine. Yet, a major limitation for long-term success of targeted therapy is relapse due to tumor heterogeneity or acquired resistance. Thus, we performed a genome-wide CRISPR-Cas9 screen to identif...

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Literature Corpus work: da8b95a0-aedc-5679-aa9c-5c52744b7083
DOI: 10.1101/2022.12.23.521745

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