Article

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

2023-01-24

Abstract excerpt

<title>Abstract</title> <p>Gain-of-function mutations in <italic>NOTCH1</italic> are among the most frequent genetic alterations in T cell acute lymphoblastic leukemia (T-ALL), making the Notch signaling pathway a promising therapeutic target for personalized medicine. Yet, a major limitation for long-term success of targeted therapy is relapse due to tumor heterogeneity or acquired resistance. Thus, we performed...

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Literature Corpus work: 7ffef929-ccd3-5a3f-b816-00009dd5df33
DOI: 10.21203/rs.3.rs-2463403/v1

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